Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3
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چکیده
منابع مشابه
Supercooling Agent Icilin Blocks a Warmth-Sensing Ion Channel TRPV3
Transient receptor potential vanilloid subtype 3 (TRPV3) is a thermosensitive ion channel expressed in a variety of neural cells and in keratinocytes. It is activated by warmth (33-39°C), and its responsiveness is dramatically increased at nociceptive temperatures greater than 40°C. Monoterpenoids and 2-APB are chemical activators of TRPV3 channels. We found that Icilin, a known cooling substan...
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ژورنال
عنوان ژورنال: The Scientific World Journal
سال: 2012
ISSN: 1537-744X
DOI: 10.1100/2012/982725